MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the 12S rRNA gene. It activates the AMPK pathway — the cell's master energy sensor — and has been shown to regulate metabolic homeostasis, improve insulin sensitivity, and prevent diet-induced obesity in preclinical models. Often called the "exercise mimetic peptide," MOTS-c promotes fat oxidation and enhances glucose uptake independent of physical activity, making it a key target in metabolic and aging research.
Categories: Peptides, Lipolysis, Mitochondrial Optimization
Tags: metabolism, AMPK, exercise mimetic, fat loss, insulin sensitivity, mitochondria